Autoimmune Disease & Inflammation
Autoimmune Disease & Inflammation
INDIGO’s assay kits and services can provide valuable information for your autoimmune disease and inflammation research. Whether you are interested in a single-receptor assay or a full-panel study, we can help you obtain the data you need quickly.
Receptors for Autoimmune Disease & Inflammation Research
Nuclear receptors and other receptors are targets for autoimmune research due to their involvement in the signaling pathways for inflammation and immunity. Autoimmune diseases also cause damage to the endocrine system causing over or underproduction of certain hormones. This makes therapies that are full or partial agonists, or antagonists of nuclear hormone receptors involved in endocrine function important for managing perturbations caused by specific autoimmune diseases.
Indigo Assays for Autoimmune Disease & Inflammation Research
INDIGO Biosciences offers assays for receptors that are implicated as promising therapeutic targets for drug discovery in autoimmune disease and inflammation:
- AR (NR3C4)
- ERα (NR3A1)
- ERβ (NR3A2)
- GR (NR3C1)
- MR (NR3C2)
- NFAT
- PGR (NR3C3)
- PPARα (NR1C1)
- PPARγ (NR1C3)
- RARα (NR1B1)
- RARβ (NR1B2)
- RARγ (NR1B3)
- RORα (NR1F1)
- RORγ (NR1F3)
- RXRα (NR2B1)
- RXRβ (NR2B2)
- RXRγ (NR2B3)
- TEAD/YAP (Hippo Pathway)
- VDR (NR1I1)
Autoimmune Disease & Inflammation
A healthy immune system defends the body against disease and infection, but if the immune system malfunctions, it can mistakenly attack healthy cells, tissues, and organs. Collectively diseases that result from dysfunction of the immune system, whether from abnormally low activity or over activity, are called autoimmune disease. These attacks can affect any part of the body, weakening bodily function and even turn life-threatening. More than 23 million people in the United States have an autoimmune disease and there are more than 80 known types of autoimmune diseases including type 1 diabetes, rheumatoid arthritis, psoriasis, and multiple sclerosis.
Many autoimmune diseases have similar symptoms. One of the classic signs of an autoimmune disease is the redness, heat, pain, and swelling caused by inflammation. Though inflammation is critical for the body’s normal immune responses, chronic inflammation has been shown to cause tissue damage. For these reasons and others, avenues for autoimmune disease research include the role of inflammation associated with immune system response.
Treatments for autoimmune diseases vary depending on the disease, but mostly consist of ways to reduce symptoms and reduce the immune systems abnormal response. Currently, the cause for autoimmune diseases is unknown but, due to the rise of incidences of autoimmune disease, researchers suspect environmental factors play a role.
EXPAND CONTENTRelated Products and Services
Drug Discovery Assay Kits
Get fast, clear, reproducible results from INDIGO’s all-inclusive reporter assay kits. No cell culture required!
Reporter Assay Services
Rapidly gain a clear overview of chemicals, pharmaceutical compounds, or environmental samples on key biological receptors.
Custom Assay Development
Contact our team of specialists and design custom assays tailored to your needs.
Related Information
[fl_builder_insert_layout id=”211187″ type=”fl-builder-template”] [fl_builder_insert_layout id=”211190″ type=”fl-builder-template”] [fl_builder_insert_layout id=”211192″ type=”fl-builder-template”]What Our Customers Say
“It just works. Everything about them, the actual assays and interacting with the customer relations team. Everything just works. It’s what you hope every company aspires to be.”
Mark Principal Scientist“The fact that they do have this comprehensive panel…essentially you can pick and choose which of the members of the panel you want to run.”
Linda Scientist“The overall experience went smoothly, and I got valuable data that helped me advance several molecules through the discovery pipeline.”
Olivia Associate Director