Nuclear Receptors and Cancer Research: Current Trends and Applications

(State College, PA; November 13, 2012) – INDIGO Biosciences, Inc., the industry’s leading provider of cell-based nuclear receptor reporter assay products and services, has added all nine retinoid receptor assays to the company’s significant suite of kits and screening services.

INDIGO Biosciences provides more than two dozen individual nuclear receptor reporter assays for scientists engaged in the discovery and development of novel therapeutic agents.

The company’s retinoid receptors include retinoic acid receptors (RARs), retinoid X receptors (RXRs) and RAR-related orphan receptors (RORs). In addition, INDIGO Biosciences offers all three subtypes of each retinoid receptor.

“Retinoid receptors bind uniquely to retinoid compounds and directly regulate gene expression,” stated Dr. Jack Vanden Heuvel, INDIGO Biosciences chief scientific officer. “They mediate a wide range of metabolic pathways and play important roles in vision, cell proliferation and differentiation, growth of bone tissue, immune function, activation of tumor suppressor genes and many others. Because of their profound effects on functions throughout the body, retinoid receptors are significant drug targets.”

INDIGO Biosciences’ ready-to-use assay systems are simple, reliable and accurate. The company’s easy-to-use lab-in-a-box assay kits can be shipped overnight so that scientists can produce data within 24 hours featuring excellent Z’ scores and high signal-to-noise ratios.

“Each kit includes reporter cells, assay plates and all reagents,” said Dr. Bruce Sherf, INDIGO Biosciences chief technology officer. “The products feature engineered reporter cells prepared using our CryoMite^™process, a long-term cryo-preservation of cells for shipping and storage and on-demand use.”

In addition, INDIGO Biosciences offers contract screening services for more than two dozen individual nuclear receptor reporter assays, including all nine retinoid receptors. The company provides fast turnaround times and easy-to-analyze data reports. Review INDIGO Biosciences’ complete catalog of on-demand screening assays.

About INDIGO Biosciences, Inc.

INDIGO Biosciences, Inc. offers products and services focused on nuclear receptors for the drug discovery and biosciences industries. The company’s unique processing method to cryo-preserve nuclear receptor reporter cells, named CryoMite^TM, provides long-term cryo-preservation of cells for shipping and storage and on-demand use. INDIGO Biosciences provides quality screening services and active ingredient determination for clients within the pharmaceutical, biotechnology, food, agriculture and nutraceutical industries and for government research agencies and academic researchers.
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